The story of Ciguatera follows Ogino, who is bullied in high school along with his friend Takai. The two rely on their passion towards motorcycles and desire to get one to add some hope and vigor to their otherwise bleak lives.

The two are learning to drive in secret at a driving school, and it is there that Ogino's life begins to change forever. The manga follows a variety of characters through their high school and working lives, through their struggles, their triumphs, their dreams, their futures, their love, life and loss.