Isola is an American ongoing fantasy comic series created by writer Brenden Fletcher and writer/artist Karl Kerschl and published by Image Comics.

The series is set in a mystical land where the queen’s brother enacts a treacherous plot to transform her into a tiger. The captain of the guard, a woman of great skill, brings swift and lethal vengeance, unaware the wicked prince alone has the power to reverse the spell. The two women—one on two legs, one on four—must undertake a perilous journey halfway across the globe to the fabled island of Isola, the gateway to the underworld, where they hope to find the spirit of the queen’s late brother, who has the power to return his sister to human form.