College freshman and ACG lover Kanji Sasahara settled down his extracurricular activity in Genshiken (The Society for the Study of Modern Visual Culture) in order to become a true and thorough otaku. Meanwhile, Saki Kasukabe, the girlfriend of another freshman Genshiken member (also a bishounen) Makoto Kohsaka, was dragged into Genshiken's otaku-ish activities reluctantly, yet her resentful attitude towards otakus is changing without her notice.

Undeterred, Saki chases Kousaka through the various activities of the club, from costume-playing and comic conventions to video gaming and collecting anime figures--learning more than she ever wanted to about the humorous world of the Japanese fan...