In the year 300X, the Maruhage Empire has subjugated the world. As a symbol of his absolute authority, Emperor Tsuru Tsurulina IV has enstated a plan to rid the world's people of their hair, the Hair Hunts! Only one man dares to fight back, Bobobo-bo・Bo-bobo! Freely wielding his nose hairs in battle he fights back against the Hair Hunters. Along his journey he is joined by a varied cast of characters in an increasingly absurd plot, where each battle is even more manic than the last!