From Wikipedia:
This story introduces Takeru who is an average Japanese highschool girl raised in a Buddhist convent by nuns. She has been experiencing reoccurring nightmares about the Witchblade calling out to her. This is due to the secret that the temple houses within, the Witchblade sealed inside a box. Furthermore, her lineage keeps an unknown connection with the mystic artifact and the folklore of the Oni, hence explaining Takeru's strong attraction to the gauntlet which is locally called Oni no te (鬼の手, "Hand of Oni"). Ultimately, Takeru's life suffers a drastic change when she becomes the next bearer of the Witchblade due to some circumstances that force her to randomly encounter it.