The series follows Eijun Sawamura, a baseball pitcher with an unusual pitching style that naturally causes the ball to move unpredictably at the plate. Sawamura plans to go with his friends to a local high school and play baseball to the best of their abilities. However, one scout from the prestigious Seido High School approaches him and offers him a scholarship and a chance to make it to the nationals. Sawamura decides to pay a visit to the school, and it changes his entire outlook on the future. Seido and their main rivals attempt to help the upperclassmen make it to nationals during the summer tournament. Once the summer tournament ends, the upperclassmen will be forced to retire, but Sawamura will help them to success, despite his lack of control.
Some time later, Sawamura and his teammates, Furuya Satoru, Kominato Haruichi and Miyuki Kazuya, lead a new team, along with a few returning faces, through the fall tournament. Their overly ambitious goal is to go to nationals during the fall tournament and convince coach Kataoka that he does not have to resign.