The main character of Gene Bride is Ichi Isahaya, who feels the difficulty of doing a job that no one can see as a woman and living a life that is not threatened by anything. One day, Makuhito Masaki, a former classmate, visits Ichi. "He was the other party of your destiny." He said he wanted to thank Ichi for an event related to "Gene Bride," a school event that matches genetic information and creates a couple of students for a one-day period. Ichi, who doesn't remember him at all, tries to remember him.