Kuragehime follows Tsukimi Kurashita, an 18-year-old who moved from Kagoshima to Tokyo to become an illustrator. Tsukimi is a jellyfish otaku who comes to live in a shared bath and toilet, women-only apartment, Amamizukan. Other tenants include fujoshi, NEETs and others who consider fashion their natural enemy, calling themselves "Amars (The Sisterhood)". One day, Tsukimi meets a fashionable and beautiful girl, Kuranosuke Koibuchi, who saves a jellyfish that is about to die at a pet shop. She later discovers that Kuranosuke is merely cross-dressing in order to evade inheritance of his father's occupation as a politician.